Advice on maintaining large site

Looking for advice on maintaining a large WP site without sacrificing speed and up time. I have run a since for 12 years and it’s grown from blog into a full fledged news and info portal with 6 main areas. As I try to maintain and improve the site more and more time is expended maintaining uptime and keeping load times low while fighting off the brute force bots.

Does anyone have any advice on how to move forward. I would like to keep the current database. I have thought of doing 6 WP installs using that database or multi site but still unclear as to what the best option would be. Great fun for any helpful advice would.

 

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