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Yeap Media replacement prevents attachment-id3 metabox form saving.
the metabox that let give an audio file A artist name and album name is broken when media replacement is enabled.
I’ve just tested with an audio file in the media library and was able to save Artist and Album just fine when Media Replacement module is active.
Maybe you have another plugin that caused the issue? How was saving ‘prevented’ for those two fields? You entered something, hit Update, but upon reload the two fields remain empty?