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It’s tested up to 6.0. there should not be anything in 6.0.1 that is a breaking change. But if you are worried at all it’s good praxis to test updates on a staging site. I really like the WP Staging plugin for that.
As for Astra, I don’t test on specific themes, but there haven’t been recent reports of any issues.
Best thing to do is to give it a test.